JonnyHu
09-23-2004, 08:11 AM
Here is a potentially relevant story that appeared in Nature (premier British science journal) in 2002 that could possibly explain Tyler's predicament:
http://www.nature.com/cgi-taf/DynaPage.taf?file=/nature/journal/v417/n6884/full/417010a_fs.html
The premise is that there are people who are "blood chimeras" - that is they have their "own" blood plus apparently the blood of someone else, most often a twin or a twin that was spontaneously aborted during pregnancy. This leads to an individual who may be carrying blood cells with two different sets of blood group markers - this is the basis of the test that nailed Tyler. So, is it possible that Tyler is one of these "blood chimeras"? There should be a simple way to determine this. They should be able to separate the blood cells that are "different" is what is called a FACS machine (Fluorescence Activated Cell Sorter). So, you isolate these cells then do a series of standard forensic type DNA tests. Is the DNA in the "different", apparently foreign, cells from a close relative of Tyler (i.e., an unknown spontaneously aborted twin; I assume he doesn't have a living twin, but I don't know this), or is it truly from an unrelated individual. If it's from an unrelated individual the situation would be grim for Tyler, but the case still would not be closed, because it is possible that in a long-ago transfusion (has he ever had one?), presumably during surgery, perhaps he was "seeded" with stem cells from the donor cells, resulting in persistance of foreign blood cells. I am a scientist, speaking somewhat outside my field, but it seems that, happily, the technology is available to sort this out
http://www.nature.com/cgi-taf/DynaPage.taf?file=/nature/journal/v417/n6884/full/417010a_fs.html
The premise is that there are people who are "blood chimeras" - that is they have their "own" blood plus apparently the blood of someone else, most often a twin or a twin that was spontaneously aborted during pregnancy. This leads to an individual who may be carrying blood cells with two different sets of blood group markers - this is the basis of the test that nailed Tyler. So, is it possible that Tyler is one of these "blood chimeras"? There should be a simple way to determine this. They should be able to separate the blood cells that are "different" is what is called a FACS machine (Fluorescence Activated Cell Sorter). So, you isolate these cells then do a series of standard forensic type DNA tests. Is the DNA in the "different", apparently foreign, cells from a close relative of Tyler (i.e., an unknown spontaneously aborted twin; I assume he doesn't have a living twin, but I don't know this), or is it truly from an unrelated individual. If it's from an unrelated individual the situation would be grim for Tyler, but the case still would not be closed, because it is possible that in a long-ago transfusion (has he ever had one?), presumably during surgery, perhaps he was "seeded" with stem cells from the donor cells, resulting in persistance of foreign blood cells. I am a scientist, speaking somewhat outside my field, but it seems that, happily, the technology is available to sort this out