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  1. #1
    jaded bitter joy crusher
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    Genetic variation fools doping tests

    http://www.nytimes.com/2008/04/30/sp...hp&oref=slogin

    A common genetic variation allows many people to take testosterone while testing negative. 67% of asian men tested and 10% of europeans carry this variant.

    What happens is that the body responds testosterone's anabolic stimulus (builds muscle) but does not metabolize the testosterone to the metabolites commonly tested for. This means that tests show normal T/E ratios for people who are seriously doping.

    There's no easy way to devise a better test at this point. Isotope Mass Spectroscopy could detect doping in people with these genes, but it's too expensive to use routinely.
    Anything that doesn't take years of your life and drive you to suicide hardly seems worth doing. ---- Cormac McCarthy

    A man can get disouraged many times, but he is not a failure until he begins to blame somebody else and stops trying --- John Burroughs

  2. #2
    Call me a Fred
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    It's obvious that the fix is to ban all Asians from sporting competitions.
    Mike

    -----------------------------------------------------------------------------------
    You may starch my jumper
    Hang it upside your wall
    You know by that, baby
    I need my ashes hauled.

    Sleepy John Estes

    H

  3. #3
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    Does this genetic variation also create the presence of synthetic testosterone?

  4. #4
    jaded bitter joy crusher
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    Quote Originally Posted by Bianchigirl
    Does this genetic variation also create the presence of synthetic testosterone?
    Nope. That's why IRMS can catch dopers who have this variant.

    The problem is that IRMS is much too expensive to use on all competitors, so currently they test T/E ratios cheaply and then use IRMS only on competitors like Landis, who have high T/E.

    The problem here is that if Landis had had this gene, the T/E test would never have flagged him, so they would not have done the IRMS test and he would have gotten away with it.
    Anything that doesn't take years of your life and drive you to suicide hardly seems worth doing. ---- Cormac McCarthy

    A man can get disouraged many times, but he is not a failure until he begins to blame somebody else and stops trying --- John Burroughs

  5. #5
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    Quote Originally Posted by Bianchigirl
    Does this genetic variation also create the presence of synthetic testosterone?
    No but the same people who told us this test was foolproof (though now it turns out there's a 30% false negative, 14% false positive rate) are the ones telling us the IRMS test is also perfect.

  6. #6
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    So why not screen for the polymorphism and test those with the variation using IRMS? This allows for only testing athletes who may bypass the T:E test.
    Quote Originally Posted by uzziefly
    One word : wtf??
    Quote Originally Posted by Mel Erickson
    That's three.

  7. #7
    jaded bitter joy crusher
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    Quote Originally Posted by jspharmd
    So why not screen for the polymorphism and test those with the variation using IRMS? This allows for only testing athletes who may bypass the T:E test.
    Fine article says there may be ethical issues requiring genetic testing and even if you could get around that barrier, testing even 10 percent of riders routinely with IRMS would be prohibitively expensive.
    Anything that doesn't take years of your life and drive you to suicide hardly seems worth doing. ---- Cormac McCarthy

    A man can get disouraged many times, but he is not a failure until he begins to blame somebody else and stops trying --- John Burroughs

  8. #8
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    Quote Originally Posted by Fredke
    Fine article says there may be ethical issues requiring genetic testing and even if you could get around that barrier, testing even 10 percent of riders routinely with IRMS would be prohibitively expensive.

    Sorry, only skimmed the article. Thanks for the response.
    Quote Originally Posted by uzziefly
    One word : wtf??
    Quote Originally Posted by Mel Erickson
    That's three.

  9. #9
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    Quote Originally Posted by Bianchigirl
    Does this genetic variation also create the presence of synthetic testosterone?
    Perhaps it can cause you to increase your Hct from 44.8 to 48.2 in the third week of the Tour?

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