Actually, it makes some sense to have the left side of the chain links (their inner part) shaped to optimize upshifts, while the right side of the links (their outer part) is more strong and less / differently ramped.. or something.
I think you'll be fine though using a 6600 RD and a 28 T large sprocket
If you're going with a 11-28 cassette though, make sure your chain is long enough, so the RD doesn't touch the large sprocket in small ring / large sprocket combination..
(with a compact crank for instance and large range cassette, there'll be a chance to overshorten the chain, if the small-small method is used..)
Though I think that must be cared for, with any type of short cage derailler...